It seems like a lifetime, but it was only one year ago that the world learned about a cluster of pneumonia cases linked to a live animal market in Wuhan, China. The cause: a new coronavirus, SARS-CoV-2, that leads to a disease called COVID-19. Fast forward one year, and the US has seen more than 400,000 COVID-19 deaths and more than 25 million confirmed cases — but also remarkable scientific innovation and reasons for optimism.