LOS ANGELES — Rini Kramer-Carter has tried everything to pull herself out of her dark emotional hole: individual therapy, support groups, tai chi and numerous antidepressants.
The 73-year-old musician rattles off the list: Prozac, Cymbalta, Lexapro.
“I've been on a bunch,” she said. “I still cry all the time.”
She has what's known as “treatment-resistant depression.” It's commonly defined as depression that doesn't respond to two different medications when taken one after the other, at the right dose and for the right amount of time.
