Doctors are free to prescribe medications off-label, and in some cases patients benefit from those prescriptions. Physicians may find that an off-label drug is more effective at treating a problem than medications specifically approved for that use. For example, amitriptyline, approved to treat depression, is often used off-label for migraines.
The study, published in the journal JAMA Internal Medicine in November, suggests doctors should take greater care in choosing when to use off-label drugs and to more closely monitor patients receiving them, said Chester Good, a physician with the Department of Veterans Affairs, VA Pittsburgh, who co-wrote an editorial accompanying the study.
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