Since 1946, federal funding of civilian scientists in biomedical research by the National Institutes of Health (NIH) has been guided by expert review by scientific peers. NIH science funding, the largest single U.S. government source of such support, has shrunk steadily (as measured in inflation-adjusted dollars) since 2003, which marked the end of a period during which the NIH budget had doubled. The award rate has therefore declined — a problem that's been exacerbated by growth in the number of grant applications submitted. Applications for NIH Research Grants, Grants Awarded, and Success Rates, 1998–2014.). Since review scores are seen as the proximate cause of a research project's failure to obtain support, peer review has come under increasing criticism for its purported weakness in prioritizing the research that will have the most impact